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February 1, 2019: At Journal Club, our experts sat down to discuss a paper on patterns of glia repair and remyelination in antibody-mediated models of MS.
Liu et al 2018 - Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of MS and NMO
MS is associated with antibody-mediated pathology and recombinant antibodies can cause demyelination in central nervous system (CNS) tissue. This team of researchers used MS specific antibodies to create models of demyelination in order to study the disease-specific glial cell response and the process of remyelination. They found that microglia, the immune cells of the central nervous system, need to be activated in order for remyelination to occur. This information could be used to develop therapies that promote remyelination in MS patients. Further research needs to be completed to determine the differences in remyelination processes between disease subtypes.