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January 24, 2020: At Journal Club, our experts sat down to discuss a paper on the effect of thrombin on demyelination in MS.
Yoon et al 2020 - Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain
Previous research has demonstrated that when thrombin, an enzyme involved in clotting, is decreased, myelin development is accelerated. This research group investigated this by studying a particular thrombin receptor, PAR1. They used a mouse model that lacked PAR1 and saw that it induced remyelination. Their results demonstrate that PAR1 may act as a “switch” in MS that affects remyelination mechanisms. Further research is necessary to analyze the broader effects of PAR1 and how to create a treatment that depends on this mechanism.