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The journal Neurology® Neuroimmunology and Neuroinflammation accepted a paper by lead author Dr. Fozia Mir entitled, “Cerebrospinal fluid isoprostane levels are a biomarker of oxidative stress in multiple sclerosis.” The paper is authored by Dr. Mir, Donald Lee, Hetal Ray, and Saud A. Sadiq, MD and in it the team has identified a lipid, 8-iso-prostaglandinF2α (8-iso-PGF2α), as a biomarker for disease activity and oxidative stress in the cerebrospinal fluid (CSF) of multiple sclerosis patients. Levels of this biomarker in 231 MS patients (including RR, PP, and SP subtypes) were found elevated compared to controls with the most striking values in a subgroup of SPMS patients. This is an important new area of research because it provides an objective measure to test for oxidative stress in MS patients and the response of these levels to therapeutic intervention can now be tested.
Publication: CSF isoprostane levels are a biomarker of oxidative stress in multiple sclerosis
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