Tisch MSRCNY Research Published in Brain Communications

Monday, August 22, 2022

The Larry G. Gluck Division of ALS Research located at the Tisch MS Research Center of New York has published research in Brain Communications

In this study, Tisch researchers developed a first-of-its-kind cerebrospinal fluid-mediated mouse model to identify apolipoprotein B-100 (ApoB) as a key agent causing permanent motor disability, motor neuron degeneration, and other hallmark pathology in sporadic amyotrophic lateral sclerosis (sALS). The research also found that targeted removal of ApoB from sALS cerebrospinal fluid, via filtration or immunodepletion, can prevent this process of motor neuron degeneration, which could potentially be a novel treatment strategy for patients with sALS, the form of ALS that affects 90% of patients.
Additionally, the research was profiled in leading healthcare publication STAT News, in an article that featured interviews with Director and Chief Research Scientist Dr. Saud A. Sadiq and Research Scientist Dr. Jamie Wong.


Read the research paper in Brain Communications here.

Read the feature story in STAT News here.

Read the full press release here.

Read the feature story in The Science Advisory Board here

Read the feature story in ALS News Today here



*Also noted in Kaiser Health News, the morning briefing & MedPage Today!

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